How can decision makers be supported in the improvement of an emergency? A simulation optimization and data mining approach
This paper presents a novel approach in healthcare in which Discrete Event Simulation, Simulation-Based Multi-Objective Optimization and Data Mining techniques are used in combination. This methodology has been applied for a system improvement analysis in a Swedish emergency department.
Inverse analysis approach for determining the superplastic behaviour of the Titanium alloy Ti6Al4V-ELI
superplastic behaviour Ti6Al4V-ELI
Synthesis, cytotoxicity and antiviral evaluation of new series
The entire molecular dynamics (MD) simulation and data analysis procedure was optimized by Amber 14 in modeFRONTIER that allowed to define a molecular rationale for the anti-BVDV activity.
Use of Parametric Finite Element Models to Investigate Effects of Occupant
This research project aims to investigate the effects of age, sex, and BMI on variations in LX geometry, material properties, body size, and body shape and the effects of these variations on lower-extremity injury risk. This was accomplished by performing simulations with male and female human body FE models that have geometry and material properties that are parametric with age, BMI, and stature. The optimization process was run in modeFRONTIER.
Combining 1-D components to extract pattern information_It is about more than component similarity
This study records vergence eye movements in humans in order to further refine our understanding of how components are combined to extract pattern disparity from stereo plaids. Two descriptive models were developed and were fit to the data using a multiobjective genetic algorithm under the optimization software package modeFRONTIER.
Computational Fluid Dynamics-Based Design Optimization
An optimization method has been designed for improving the performance of Archimedes screw axial rotary blood pumps. The advantages of the established pump design theory are combined with modern computer-aided, computational fluid dynamics (CFD)- based design optimization. modeFRONTIER and ANSYS are coupled in this optimization process.
Vehicular causation factors and conceptual design modifications to reduce aortic strain in numerically reconstructed real world nearside lateral automotive crashes
This study aims to find an effective means of substantially improving the outcome of motor vehicle crash induced aortic injuries. A DOCE study was performed on 16 different combinations of five design factors generated using a Latin Square method in modeFRONTIER 4.0. The experiment utilized FE vehicle models and the Wayne State Human Body Model.
Heuristic optimization of a continuous flow point-of-use UV-LED disinfection reactor using computational fluid dynamics
A numerical optimization routine using modeFRONTIER and COMSOL Multiphysics was coupled with Computational Fluid Dynamics to determine the most efficient UV-LED disinfecting reactor under specified design constraints.
Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma
This report is on the molecular mechanisms of resistance to vismodegib in two cases of basal cell carcinoma, with clinical, molecular and in silico evidence of primary and acquired SMO mutation-mediated resistance. The entire MM-PBSA computational procedure was optimized by modeFRONTIER.
Application of Optimization Methodology and Specimen Speciﬁc Finite Element Models for Investigating Material Properties of Rat Skull
This study represents a preliminary effort in the development and validation of FE models for the rat skull used to predict the reaction of traumatic brain injuries (TBI) in humans. modeFRONTIER automatically updated input parameters and submitted new keyword files to LS-DYNA, which ran in MPP mode, to reduce the time needed in completely the task. This same method can be used to other reverse engineering procedures to obtain accurate material parameters for FE models development.