Automatic evolution of enzymes for biocatalysis design | www.esteco.com

Automatic evolution of enzymes for biocatalysis design

Author: 
Valerio Ferrario, Lorena Knapic, Marco Foscato, Cynthia Ebert, Lucia Gardossi | university of Trieste

A computational infrastructure is used for integrating all the software employed for the different steps of the mutant design, modeling and scoring, within an optimization environment able to learn, generation after generation, the correlation between mutations and their efficiency, thus accelerating the evolution of the system. The framework relies on the software modeFRONTIER® that organizes a flexible and versatile work-flow. These feature makes the approach highly tunable and conversely distant from the concept of “black box”.

 

 

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