Identification of Peptides with ELAV-like mRNA-Stabilizing Effect

Marialaura Amadio, Alessia Pascale, Stefano Govoni, Raffaella Gaggeri, Daniela Rossi and Simona Collina (University of Pavia), Erik Laurini, Sabrina Pricl ( University of Trieste)

A step forward in understanding the mRNA-stabilizing effect of peptides by applying molecular modeling investigations is presented. Two peptides has been identified as valuable starting point for designing the first class of small molecules endowed with ELAV-like stabilizing effects, which could represent a highly innovative therapeutic tool. modeFRONTIER has been integrated with AMBER 11 to automate and optimize the complex workflows typically related to molecular dynamics simulations.