system biology

Multi-objective Optimization with modeFRONTIER Applied to Systems Biology

In this article modeFRONTIER was used to automate and optimize an analysis model written in MathModelica, a modelling and simulation software based on Modelica. The goal of the optimization process was not to identify a single solution to the model-fitting problem, but rather multiple solutions with acceptably small errors but at the same time with as widely varying parameters as possible.